Hb was seen to significantly improve in favour of the intervention group with aerobic training, intervention duration of less than 12 weeks as well as lasting over six months (1SO), in the supervised and initially supervised then unsupervised (one study only) group, as well as in sub-group CKD 3–4 group when compared to the control group (Online Resource 6, Supplemental Table 6). The gene discussed is GSTM1; the disease is chronic kidney disease.