Likewise, the increase in IGFBP7 × TIMP‐2 builds upon those previous findings and indicates that these urinary biomarkers reflect acute changes in commonly measured blood‐based biomarkers, such as creatinine and cystatin C. Given that dehydration is an important risk factor for acute kidney injury (Chapman et al., 2020), it is important to highlight that the lack of difference in kidney markers between the young and older groups persisted despite different levels of fluid loss (−1.81% ± 0.83% for young vs. −0.86% ± 0.68% for older, P = 0.009). This evidence concerns the gene IGFBP7 and acute kidney injury.