AD neuropathologic change (ADNC) is classically characterized by the concomitant presence of amyloid-β (Aβ) and tau pathologies.1 Neuropathological studies suggest that Aβ deposition begins in the neocortex, followed by the hippocampus and affects the striatum, brainstem, and cerebellum in hierarchical order as the disease becomes more advanced.2 In contrast, tau pathology (neurofibrillary tangles, NFTs) affects the brainstem early, followed by the limbic and neocortical areas.3 Here, MAPT is linked to Neurofibrillary tangles.