MAPT and Alzheimer disease: In addition to WNT being one of the signalling pathways involved in brain development and those related to AD,27 SNPs in WNT3 are proxies of the MAPT haplotypes H1 and H2, suggesting resilience against developing tau pathology.28 Recent studies have highlighted the involvement of WNT3a in the protective pattern from early tau phosphorylation associated with the resistance to familial AD.29 In the future, genetic assessments may augment other predictive biomarkers to help indicate patients’ risk and to sharpen personalized medical care.