Recent results revealed that stimulation of PDGFβ signalling in ccRCC cells promoted glycolysis, lactate production and histone lactylation, which in turn activated PDGFRβ transcription, suggesting that there is a positive feedback loop between histone lactylation and PDGFRβ signalling, resulting in a vicious cycle that further accelerates ccRCC progression.68 The gene discussed is PDGFB; the disease is nonpapillary renal cell carcinoma.