To investigate whether the cysts were formed due to uncontrolled proliferation, as it is seen in autosomal dominant polycystic kidney disease with mutations PKD1 and PKD2 genes [96], we assessed Ki67 staining in the epithelial cells of proximal and distal tubules and found no significant changes (figure 2f). This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.