While several subunits such as Wdr5, HCF1, and UTX have been linked to CHD (Homsy et al., 2015; Jin et al., 2017; Priest et al., 2016; Zaidi et al., 2013; Zhu et al., 2017b), the roles of most other subunits in heart development and their association with heart diseases remain largely unknown. Here, HCFC1 is linked to coronary artery disorder.