Analysis of gene expression programs for Wnt signaling in addition to other components of the Wnt pathway, such as the Wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6) and the Frizzled receptors (FZD), revealed heterogeneous expression beyond cancer cells, i.e., in endothelial cells, myeloid cells, T cells, erythroblasts, and fibroblasts (Figure S3D–F). Here, LRP6 is linked to cancer.