Since both oncocytoma and chromophobe renal cell carcinoma share frequent membranous positivity for KIT and negative staining for vimentin, markers like KIT (CD117) and vimentin may be useful for differentiating between these two subtypes of renal cell carcinoma from others, such as clear cell and papillary renal cell carcinoma variants with eosinophilic cytoplasm [3]. The gene discussed is KIT; the disease is hereditary clear cell renal cell carcinoma.