In an in vivo rat model of AD, Lins et al. reported that 1 MHz frequency, 1 Hz pulse repetition frequency (PRF), 50 ms burst duration (BD), and 5% duty cycle (DC) increased the level of BDNF, glial-derived neurotrophic factor (GDNF), and vascular endothelial growth factor in the lateral hippocampus after 15 min of stimulation (Lin et al., 2015). The gene discussed is GDNF; the disease is Alzheimer disease.