CD40 and neoplasm: HDACi regulates the expression levels of other tumor antigens suchas CD40, CD54 (ICAM-1), CD80, and CD86 in tumor cells.32−35 More specifically, the repression of CD54 expression is anotherstrategy tumors use to escape the immune response.36 HDACi have been shown to induce upregulation of CD54.32−36 To investigate the effect of our glycosylated HDACi on the expressionof CD54, we incubated Hep-G2 cells with STR-V-53 at IC50 and 2× IC50 for 24 h.