Also, we found that a representative HCC cell line (Hep-G2)largely uptakes the glycosylated HDACi through the GLUT-2 transporter.In addition, these HDACi caused HCC cell-line-dependent apoptosisthrough caspase 3 cleavage and p21 upregulation. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.