The expression of CCL16, CXCL8 and CX3CL1 has been implicatedin HCC cell invasion, metastasis, migration and M2 polarization oftumor-associated macrophages, while their suppression is associatedwith improved patient prognosis.51−53 In contrast, CCL20,CCL26, CCL25 and CXCL1 have been shown to play multifaceted roles,including oncogenic functions and predictors of better prognosis,in several tumor types.52,54−57 However, chemokines are involved in a network of interactions toregulate tumor growth and progression. The gene discussed is CXCL8; the disease is hepatocellular carcinoma.