One of the consequences of histone deacetylaseinhibition is the alteration of tumor immunogenicity in favor of enhancedantitumor immune responses.28,29 Specifically, HDACirobustly upregulates PD-L1 in human and murine cell lines and patienttumors.30,31 To investigate the effects of our glycosylatedHDACi on immune checkpoint molecules, we used immunoblotting to probefor the expression levels of PD-L1 and PD-1 in Hep-G2 cells incubatedwith lead compound STR-V-53 for 24 h. The gene discussed is CD274; the disease is neoplasm.