SLC2A1 and cancer: GLUT-1, GLUT-2, GLUT-3, andGLUT-4 are overexpressed on several cancer cell types.19,20 HCCs are known to overexpress GLUT-2, which effectively promotesthe uptake of glucose and mannose to support tumor growth, such thatGLUT-2 is recognized as a novel prognostic factor of HCC.21 GLUT-2 is a major sugar transport facilitatorin the hepatocytes, having higher capacity and lower binding affinityto glucose.20 In addition, GLUT-2 couldpromote the cell uptake of fructose and several glycosylated smallmolecules.