Adult migraine patients have elevated blood levels of TNF-α, IL-1β, IL-6, IL-18, and IL-10 during migraine episodes (Dönder et al., 2021; Perini et al., 2005; Sarchielli et al., 2006), whereas children with migraines have elevated levels of IL-1α (Boćkowski et al., 2009). This evidence concerns the gene IL6 and migraine disorder.