Found in 90% of AD plaques, 72% of the total HSV-1 brain load is found in the plaques compared to only 24% in aged normal brain plaques (Wozniak et al., 2009).Linked to ApoE4 carriers (Linard et al., 2020), Lifelong persistent infection (AlMukdad et al., 2023). Here, APOE is linked to Alzheimer disease.