MAPT and Alzheimer disease: The MAD theory integrates the Tau and Amyloid theories with the pathogen-based theories such as the endotoxin theory of AD (Brown and Heneka, 2024) and viral AD (Itzhaki, 2021; Naughton et al., 2020), and also takes into account the possible downstream mechanisms such as cuproenzyme dysfunction which we believe is highly important to include for a more complete picture of AD.