This could explain why infection of mice with oral Trepomnema denticola bacteria induces Tau hyperphosphorylation and Aβ accumulation in mice in the hippocampus with neuronal loss (Wu et al., 2022), and why filtrates of Helicobacter pylori bacteria induce Tau hyperphosphorylation in mouse neuroblastoma cells and rat brains via GSK-3β activation (Wang et al., 2014). Here, GSK3B is linked to infection.