Since Aβ, Tau, ApoE, and LL-37 can be synthesized by neurons (Lee et al., 2015; Dekroon and Armati, 2001), they represent an array of oligmerization-based antimicrobial tools that can be (re-)appropriated to confer a broad defense against multitaxonomic infections in non-immune specialized cells. The gene discussed is APOE; the disease is infection.