LRP1 and Alzheimer disease: Certain environmental factors such as aluminum exposure (that can aggregate Aβ) (Kawahara and Kato-Negishi, 2011), and raw copper exposure in drinking water (that can exacerbate AD by suppression of LRP1) (Brewer, 2014; Hsu et al., 2019), may not necessarily compete with MAD, but instead could be also integrated through common pathways.