In this regard, HSV-1 infection of SHSY-5Y Neuroblastoma induce a 3-fold increase in levels of phosphorylated Tau, with GSK-3β responsible for the phosphorylation of Threonine-212 and Serine(s)-202, 396, and 404 in conjunction to PKA phosphorylation of Serine 214 (Wozniak et al., 2009). This evidence concerns the gene MAPT and neuroblastoma.