For innate immune responses to viruses it is important to note that the most common mutation (R47H) in the microglial phagocytic triggering receptor expressed on myeloid cell 2 (TREM2) is a strong risk factor for AD and is characterized by an enhanced type 1 IFN response (Korvatska et al., 2020; Guerreiro et al., 2013). The gene discussed is TREM2; the disease is Alzheimer disease.