MAPT and Alzheimer disease: Furthermore, Aβ is able to promote the hyperphosphorlyation of Tau in both the cytosolic and synaptic compartments, which has been suggested as a potential explanation of the prion-like “seeding” hypothesis of Tau transmission inter-neuronally, accounting for the phosphorylated Tau detected in the CSF of AD patients (Wu et al., 2018; Ferreira et al., 2014; Bennett et al., 2017).