The research yielded three key findings: (1) the establishment of hypoxia-related 8-lncRNA risk signature, characterized by distinct molecular, biological, and clinical features; (2) the identification of a positive association between this risk signature and HGG immunosuppression; and (3) the demonstration that suppressing TP73-AS1, a representative hypoxia-related lncRNA, enhances the anti-tumor response in HGG cells. This evidence concerns the gene TP73 and neoplasm.