TP73 and central nervous system cancer: In in-house glioma samples, we detected TP73-AS1, HIF1α, IBA-1, and TGF-β, which revealed that patients with elevated TP73-AS1 expression showed increased TAM (IBA-1+) infiltration and higher levels of HIF1a and TGF-β (Figures 7A, B), indicating a positive relationship between hypoxia-related TP73-AS1 and tumor immunosuppression.