Excess glutamate (Glu) can induce excessive mitophagy by activating the glutamate receptor 2 (GluR2)-Parkin pathway, leading to mitochondrial dysfunction, apoptosis of hippocampal neurons, a deficiency in monoamine neurotransmitters, and the development of diabetes-related depression (DD) in rats (132). This evidence concerns the gene GRIA2 and dentin dysplasia.