Paired t-tests suggested that compared with normal lung tissue, LRRC8C mRNA was significantly down-regulated in combined lung squamous cell carcinoma (LUSC) + lung adenocarcinoma (LUAD) (Figure 7A), LUSC, and LUAD (all P < 0.0001) (Supplementary Figures 6A, B). This evidence concerns the gene LRRC8C and lung adenocarcinoma.