To evaluate accumulative effect of the three independent SNPs on NSCLC survival, we combined their unfavorable genotypes (i.e., LRRC8C rs10493829 TT, OAS2 rs2239193 AG+GG, and CCL25 rs3136651 TT) into a genetic score that was used to categorize all NSCLC patients into four groups (i.e., 0, 1, 2, and 3) by the number of their unfavorable genotypes (NUG). The gene discussed is OAS2; the disease is non-small cell lung carcinoma.