In a dominant genetic model, compared with the reference genotype, NSCLC patients had a poor survival associated with LRRC8C rs10493829 TT (OS: HR = 1.18, 95% CI = 1.01-1.37, P = 0.035), OAS2 rs2239193 AG+GG (OS: HR = 1.38, 95% CI = 1.11-1.70, P = 0.003; DSS: HR = 1.43, 95% CI = 1.15-1.78, P = 0.001) and CCL25 rs3136651 TT (OS: HR = 1.20, 95% CI = 1.02-1.40, P = 0.024; DSS: HR = 1.19, 95% CI = 1.01-1.40, P = 0.037). This evidence concerns the gene OAS2 and non-small cell lung carcinoma.