Oxazolone+HDM mice displayed severer AD-like symptoms, hyperkeratosis and lymphocyte infiltration, and higher MIF mRNA and stronger MIF immunofluorescence signals in skin, similar to MC903+HDM mice; while oxazolone without HDM mice showed slight AD-like presentations (Supplementary Figures S2B–G), indicating that Der f1 rather than MC903 is the main allergen to produce the AD model. The gene discussed is MIF; the disease is Hyperkeratosis.