EVs derived from MSC-TRAIL were found to exhibit cytotoxicity against neuroblastoma cell line (SHEP-TET), human breast adenocarcinoma line (MDAMB231), renal cancer lines (HA7-RCC and RCC10), malignant pleural mesothelioma lines (H2818, H2810, H2804, and H2795) and lung cancer lines (NCI-H727, NCI-H460 and A549) without any cytotoxic effects towards primary human bronchial epithelial cells (108). The gene discussed is TNFSF10; the disease is lung cancer.