IFNG and neoplasm: IL-12-secreting MSCs embedded in Matrigel (MSC-IL-12-Matrigel) also inhibited tumour growth in immunodeficient murine models, such as the severe combined immunodeficient murine (SCID) model, and beige/nude/X-linked immunodeficiency (BNX) mice lacking T and B lymphocytes (T and B cells) and NK cells, but not in IFN-γ knockout murine models (47).