IFNB1 and neoplasm: Meanwhile, intratumorally generated IFN-β was found to suppress primary tumour growth and attenuate pulmonary and hepatic metastases by downregulating activation of matrix metalloproteinase-2 (MMP-2), signal transducer activator transcription factor 3 (Stat3), cellular Myc (c-Myc), protein kinase B (Akt), and proto-oncogene tyrosine-protein kinase (Src) expression in tumour cells (62).