Ten studies were eligible for inclusion in the analysis of cholangitis, 11 for choledocholithiasis, 5 for malignancy, 5 for SOD, and 4 for acute pancreatitis.1–3,11,12,14,16,20,22–25,27,28,30–32 Hemorrhage was not significantly associated with any indication cholangitis (OR 1.50; 95% CI 0.97–2.32), choledocholithiasis/biliary stone (OR 1.28; 95% CI 0.95–1.73), malignancy (OR 0.97; 95% CI 0.66–1.42), SOD (OR 1.32; 95% CI 0.72–2.40), or acute pancreatitis (OR 0.81; 95% CI 0.44–1.49) during the meta-analyses (Figure 2A–E). The gene discussed is SOD1; the disease is choledocholithiasis.