A similar finding was observed in the LLC xenograft C57BL/6 N mouse model, which showed that treatment with βT3 reduced tumour size, reduced PD-L1 expression, as well as inhibition of JAK2/STAT3 pathway, increased CD8+ T-cell population and elevated granzyme B levels [40] (Table 1). The gene discussed is STAT3; the disease is neoplasm.