In a separate study, it was shown that supplementation of D-α-tocopherol succinate (2 mg/kg body weight) inhibited the immunosuppressive activities of MDSCs in lung cancer-bearing C57BL/6 mice, where the authors reported a reduction in the tumour size and infiltration by MDSCs in the TME and increased levels of CD8+ T-cells in the tumours from vitamin E-treated mice [38] (Table 1). The gene discussed is CD8A; the disease is neoplasm.