CD4 and breast cancer: For instance, supplementation of α-tocopheryloxyacetic acid (α-TEA), a derivative of αToc, showed a significant reduction in the tumour size, increased activated CD4+ and CD8+ T-cell populations, reduced the levels of the immunosuppressive T-regulatory (Treg) population, higher levels of IFN-γ secretion, and lower levels of IL-4 in a syngeneic mouse model of BC, which supports Th1 or cell-mediated immune response [30] (Table 1).