IRF4 and breast cancer: Furthermore, supplementation of γT3 in the same mouse model of BC induced epigenetic changes in several genes, such as homeobox A10 (HOXA10) (reduced methylation), interferon-regulatory factor-4 (IRF4) (hypermethylation), and retinoic acid receptor–related orphan receptor alpha (RORα) (hypermethylation) in CD4+ T-cells isolated from these animals [32] (Table 1).