Although mutations in USH2A and LOXHD1 can be associated with mechanotransduction defects in cochlear hair cells and hearing loss (Mori et al., 2015; Hartel et al., 2016; Lee et al., 2020; Trouillet et al., 2021; Crane et al., 2023), any potential peripheral contributions to vertigo of the patient caused by mutations in these two genes can be excluded due to bilateral vestibular neurectomy, which supports the hypothesis of a central vertigo mediated by the KCNC3 variant. This evidence concerns the gene USH2A and Vertigo.