Hemoglobinopathies are the most frequently encountered mono-gene disorders in humans.1 Beta Thalassemia major is one such hemoglobinopathy due to reduced or absent synthesis of beta-globin chain, which causes a decreased production of red blood cells and low haemoglobin content, eventually leading to anaemia.2 Hemoglobinopathies were earlier restricted to particular geographical regions, but now a more global distribution is observed owing to immigration and ethnic globalization. The gene discussed is HBB; the disease is hemoglobinopathy.