This difference may be due to the greater specificity of ALT for hepatic tissues, whereas AST is less specific and present in many tissues.17 In another study conducted by Hammod et al. in 2019, on comparison of thalassemia patients with control group, a significant increase in iron and liver enzymes was observed.21 Similarly, Suman RL et al in their study also recorded iron deposition to cause compromised functioning of the liver with raised AST and ALT.22 The gene discussed is GPT; the disease is thalassemia.