Specifically, it increases the number of local neutrophils within the tumor microenvironment, and accelerates tumor metastasis and infiltration.26,27 The results of our study showed that the serum levels of IL-6, TNF-α, and IL-8 in the observation group were lower than those in the control group after the treatment, indicating that chemotherapy combined with SMI can effectively alleviate inflammatory reactions in patients with advanced CRC. Here, TNF is linked to neoplasm.