TNF and colorectal cancer: As a pro-inflammatory factor, TNF-α can promote the onset and progression of tumors.23 IL-6 and IL-8 are both important factors closely related to the onset and progression of colorectal cancer.24,25 IL-6 can accelerate tumor cell proliferation and growth, affect immune cell function, and promote the progression of CRC.26 IL-8 has functions such as regulating vascular permeability and proliferation, and promoting tumor vascular proliferation.