TNF and colorectal carcinoma: Specifically, it increases the number of local neutrophils within the tumor microenvironment, and accelerates tumor metastasis and infiltration.26,27 The results of our study showed that the serum levels of IL-6, TNF-α, and IL-8 in the observation group were lower than those in the control group after the treatment, indicating that chemotherapy combined with SMI can effectively alleviate inflammatory reactions in patients with advanced CRC.