NFKB1 and Parkinsonism: Topically, it is used to relieve excruciating spasms in the muscles. It is also used to treat a wide range of conditions, which include surgical pain, cervicobrachial neuralgia, acute to chronic torticollis, Parkinson's disease, drug-induced Parkinsonism, spastic hemiplegia, tooth soreness, acute lower back pain, etc. THC is used in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants, and analgesics. By downregulating and inhibiting the synthesis of NF-κB-regulated gene products, it possesses anti-inflammatory properties.