This includes a mediating role for epigenetics (eg, DNA methylation) [59], inflammatory markers (eg, C-reactive protein) [60], markers of chronic stress [61], sex-specific biological factors (eg, sex hormones) [62], and immune system dysregulation and adipokine secretion [61], any of which could increase adipose tissue accumulation, central fat deposition, or insulin resistance [59-61, 63-65]. This evidence concerns the gene CRP and Insulin resistance.