FN1 and neoplasm: Lugo-Cintrón et al. (2020), using an in vitro 3D microfluidic model of the breast TME reproducing a tumor mass invading the stroma, showed that in the presence of normal breast fibroblasts, a fibronectin-rich collagen matrix increases metastatic MDA-MB-231 TNBC cells migration, due to an overexpression of matrix metalloproteinases secreted by the normal fibroblasts (Lugo-Cintrón et al., 2020).