These authors showed that the BC cells exposed to a high magnitude of fluidic shear stress (10 dyn/cm2) overexpressed the proliferation marker Ki67 as well as a higher phosphorylation level of proteins usually associated with a more aggressive phenotype in CTCs, such as p-AKT, p-mTOR, and p-STAT3, whereas no changes in p-ERK1/2 have been observed (Ortega Quesada et al., 2024). Here, AKT1 is linked to breast cancer.