It is known that bone recurrence occurs preferentially in luminal breast cancer (LBC) (Wu et al., 2023), HER2-positive tumors have the highest rates of metastasis to the liver (Rashid et al., 2021), while TNBC and basal-like subtype often develop metastases in brain that represents a challenge for cancer cells due to the blood-brain barrier (BBB) (Lee et al., 2015). The gene discussed is ERBB2; the disease is breast cancer.