Thus, Piotrowski-Daspit et al. (2016) used a 3D microfluidic culture model to obtain aggregates of MDA-MB-231 human BC cells embedded within a gel of type I collagen to demonstrate that elevated interstitial fluid pressure within the core of solid tumors increases the BC cells collective invasion from primary tumor via SNAIL, vimentin (VIM), and E-cadherin (CDH1), all of them associated with the EMT process (Piotrowski-Daspit et al., 2016). The gene discussed is SNAI1; the disease is breast cancer.