This case report describes the detailed obstetric course of a 44‐year‐old woman with PNH and additional hereditary protein C deficiency who had previously experienced multiple thrombotic events and adverse pregnancy outcomes (two early miscarriages and one stillbirth at 25 weeks gestation [WG]), treated with eculizumab (terminal C5 inhibitor) and optimal anticoagulation management. The gene discussed is C5; the disease is paroxysmal nocturnal hemoglobinuria.