Warm AIHA is caused by immunoglobulin G (IgG) that opsonizes RBCs at body temperature, while cold AIHA is caused by immunoglobulin M (IgM) that binds to RBC at temperatures below body temperature leading to complement fixation and primarily extravascular hemolysis [1, 2] In mixed AIHA, there is the presence of both warm and cold autoantibodies. Here, CD40LG is linked to autoimmune hemolytic anemia.