The levels of amylase and lipase in serum (Figure 5D), trypsin activities (Figure 5E), ductal tubular complexes (Figure 5F,G), CD3+ T lymphocyte infiltration (Figure 5F,H), and CD11b+ macrophage (Figure S7B,C) in pancreatic tissue with L‐Arg‐induced acute pancreatitis were dramatically reduced by VB12 treatment. This evidence concerns the gene ITGAM and acute pancreatitis.