Researches indicate that anthraquinone in rhubarb attenuated renal fibrosis through inhibit the TGF-β/Smad, P38/MAPK, SIRT3/FOXO3/SOD2, PERK/ATF4/CHOP, P13K/Akt/mTOR signaling pathways (Wang et al., 2022). Here, TGFB1 is linked to renal fibrosis.