Furthermore, based on TMB and HGB level, we divided the 1,479 cancer patients into four groups: TMB-high and HGB-high (TMB > 10/mb and HGB ≥ 110 g/L), TMB-low and HGB-high (TMB ≤ 10/mb and HGB ≥ 110 g/L), TMB-high and HGB-low (TMB > 10/mb and HGB < 110 g/L), and TMB-low and HGB-low (TMB ≤ 10/mb and HGB < 110 g/L). Here, CYGB is linked to cancer.