Notably, the HGB level showed no significant correlation with OS and PFS in most of the TCGA cancer cohorts (log-rank test, P > 0.05), except that the HGB level had significant positive correlations with OS in LAML and PRAD and significant negative correlations with PFS in MESO (log-rank test, P < 0.05) (Supplementary Figure S2). This evidence concerns the gene CYGB and cancer.