The molecular interactions between molecules 3,874,518, 5,281,600, and 12,314,417, which target the MH2 domain of SMAD3, are essential for influencing the TGF-β signaling pathway implicated in conditions such as DMD, which is distinguished by an excessive accumulation of fibrosis (Chen et al., 2014). Here, SMAD3 is linked to Duchenne muscular dystrophy.