Limb-girdle muscular dystrophy (LGMD) is a progressive muscle weakness affecting the pelvic and shoulder girdles, primarily caused by mutations in proteins like myotilin, lamin, caveolin-3, calpain-3, dysferlin, γ-sarcoglycan, TCAP, TRIM32, FKRP, and titin. The gene discussed is CAPN3; the disease is limb-girdle muscular dystrophy.