Limb-girdle muscular dystrophy (LGMD) is a progressive muscle weakness affecting the pelvic and shoulder girdles, primarily caused by mutations in proteins like myotilin, lamin, caveolin-3, calpain-3, dysferlin, γ-sarcoglycan, TCAP, TRIM32, FKRP, and titin. Here, TTN is linked to limb-girdle muscular dystrophy.