BCL2 and melanoma: Additionally, the investigation into the gene expression patterns of Bax and Bcl-2 in MCF-7 and A-375 cells after their exposure to both nanosystems unveiled an elevation in their ratio of Bax/Bcl-2 (>1), indicating a significant increase in apoptosis in the treated cancer cells.197 Current findings highlight the potential of polymeric alginate nanoparticles as nanocarriers for application against breast and melanoma cancers.