Also, hyperoxic conditions might further enhance the cytotoxic activities of the tested compounds, attributed to the increased oxidative stress and apoptosis induction that accompany such conditions helping prevent the proliferation and survival of cancer cells.198 Moreover, Alg-EOs-NPs and Alg-β-pinene-NPs showed significant induction in the apoptosis in MDA-MB-231 and A-375 cells confirmed by an increased Bax/Bcl-2 ratio, as evidenced by the upregulation of Bax (a pro-apoptotic protein) and the downregulation of Bcl-2 (an anti-apoptotic protein).198. This evidence concerns the gene BCL2 and cancer.