According to de Oliveira et al. [63] and Küppers et al. [64], the activation and deregulation of the NF-κB complex is a critical feature in the pathogenesis of KSHV, with similar features to EBV-induced tumorigenesis in Reed Sternberg tumor cells of Hodgkin lymphoma. This evidence concerns the gene NFKB1 and Hodgkins lymphoma.