SSc fibroblast exosome RNA induced a 2.5‐fold increase in MX1 (P = 0.002), 2‐fold increase in CXCL10 (P = 0.0015), and 3‐fold increase in CXCL11 (P = 0.016) expression in HaCaTs (Figure 5F–H). This evidence concerns the gene CXCL10 and systemic sclerosis.