Gene ontology enrichment analysis using the fold changes for all detected genes revealed that several pathways involved in immune signaling (responses to type 1 IFN, responses to IFN‐γ, humoral immune responses, and response to chemokines) were up‐regulated in HaCaTs stimulated with SSc fibroblast exosomes compared to healthy fibroblast exosomes (Figure 4A). Here, IFNG is linked to systemic sclerosis.