Aside from the any stroke and ischemic stroke signals, which were partially replicated by Apo-A1 weighted MRs, the associations with CHD, small vessel stroke, HF and AAA were fully replicated by cis-MR analyses selecting and weighting CETP variants by their associations on Apo-A1 or Apo-B concentration; Fig. 2. The gene discussed is APOA1; the disease is ischemic stroke.