The apolipoprotein (both Apo-A1 and Apo-B) weighted analyses replicated the effect on LBD in APOE-ε4 carriers, with the Apo-A1 weighted analysis also replicating the associations for dementia in PD, as well as the ALS association; Fig. 3. The gene discussed is APOA1; the disease is amyotrophic lateral sclerosis.