GLA and Fabry disease: Fabry disease (FD, OMIM 301500) is an X-linked chromosomal disorder caused by a pathogenic variant in the GLA gene, which leads to decrease the activity of α-galactosidase A (α-Gal A) and progressive accumulation of complex sphingolipids, predominantly globotriaosylceramide (Gb3) and lyso-globotriaosylceramide (lyso-Gb3) [1].