Our results indicated that macrophage rhythms are disordered within tumors (Figs. 6 and 7), and that heterogeneity in rhythms within the tumor-associated macrophage population may underlie this observed circadian disorder (Figs. 8 and EV5), which was supported by our observations of heterogeneity in circadian clock gene expression within the TAM population from scRNA-sequencing data (Fig. 9). This evidence concerns the gene CLOCK and neoplasm.