IL4 and Allergy: While these type 2 stimuli play a role in response to parasites and allergy, they are also major drivers of wound healing; in line with this, IL-4 and IL-13-stimulated macrophages have been well-characterized to adopt gene expression profiles associated with wound-healing and anti-inflammatory macrophage phenotypes (Allen, 2023; Mantovani et al, 2013; McWhorter et al, 2013; Pesce et al, 2009).