As a consequence, JAM2, JAM3 (junctional adhesion molecule 2 and 3 [MIM: 606870 and 606871]), OCLN (occludin [MIM: 602876] and ESAM (endothelial cell adhesion molecule [MIM: 614281])dysfunction can present with overlapping clinical features showing severe developmental encephalopathies and epilepsy. The gene discussed is ESAM; the disease is epilepsy.