The addition of activated autologous T cells to tumor-MDM co-cultures resulted in a robust reversal of the baseline MDM/TAM phenotype with significantly increased expression of proinflammatory factors including CXCL9 (C-X-C motif chemokine ligand 9), CXL10 (C-X-C motif chemokine ligand 10), CXCL11 (C-X-C motif chemokine ligand 11), and CCL5 and reduction of IL10 in tri-cultures over co-cultures in the context of both LNCaP and 22Rv1 tumor cells (Fig. 3B). Here, CXCL9 is linked to neoplasm.