In line with this, ORCHID detected more modest decreases in the magnitude of DFGABAA between baseline and immediately prior to the SLE (< 15 s prior to SLE onset) in both CaMKIIα+ pyramidal neurons and GAD2+ interneurons (Fig. 4b, d), suggesting that DFGABAA begins to break down before SLE onset (Supplementary Fig. 9). This evidence concerns the gene GAD2 and systemic lupus erythematosus.