For example, with a k-means clustering technique, in a multicenter population of patients with CS, a study described 3 phenotypes determined by 6 laboratory variables at admission (white blood cell and platelet counts, glomerular filtration rate, ALT, lactate, bicarbonate), called “non-congestive”, “cardio-renal” and “cardio-metabolic” [88]. Here, GPT is linked to Cowden syndrome 1.