After high salt, the phenotype of the SS rats with I26T mutation is dramatically different from the SS rats lacking Kir5.1 (SSKcnj16−/−), where SSKcnj16−/− rats present low blood pressure, severe hypokalemia, and salt wasting phenotype (Palygin et al., 2017). The gene discussed is KCNJ16; the disease is Hypokalemia.