Although we have clearly shown that eIF3a is regulated by Wnt/β-catenin signaling pathway in cell-based studies and that APC mutation up-regulates eIF3a expression in the APCmm/+ animal model, it remains to be determined if the increased eIF3a expression in human colon cancers is due to APC mutation in these cancers. Here, APC is linked to malignant colon neoplasm.