Treatment of T2DM evolved from lifestyle changes and diet to oral antidiabetics like metformin, sulfonylureas, thiazolidinediones and dipeptidyl peptidase-4 (DPP-4) inhibitors and eventually injectable glucagon-like peptide-1 (GLP-1) agonists and insulin taking over the treatment landscape [6]. The gene discussed is GCG; the disease is type 2 diabetes mellitus.