FOXO1 and obesity due to melanocortin 4 receptor deficiency: PI3K/AKT was suggested to regulate glucose metabolism through Forkhead box protein O1 (FoxO1) and glycogen synthase kinase 3 (GSK-3) and lipid metabolism through mammalian target of rapamycin complex 1 (mTORC1) and SREBP in obesity and T2DM [14].