MLXIPL and chronic kidney disease: FA metabolism is regulated by AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α), PPARα, carbohydrate response element-binding protein (ChREBP), and sterol regulatory element-binding protein (SREBP) [2], where SREBP mediates the progression of CKD, including lipid-dependent and lipid-independent pathways [5].