SAG and diabetes mellitus: Although the dBRD9‐loaded MN patch exhibited a significantly better healing effect than the blank vector‐loaded MN patch, the SAG‐loaded MN patch exhibited no apparent effect on wound healing in DM, which is consistent with the above finding in vitro that without a bona fide immune microenvironment, Hh signaling activation alone fails to effectively rescue the suppressed proliferation ability of dermal fibroblasts and vascularization of endothelial cells.