To this end, we modeled precancerous pancreatic lesions and development of pancreatic cancer by targeting mice developing pancreas with a conditional oncogenic KrasLSL-G12D allele regulated by a constitutively expressed Cre recombinase, under the control of the Pdx1 promoter, commonly referred to as Pdx1-Cre KrasG12D/+ (henceforth referred to as KC KrasG12D/+; ref. 15). The gene discussed is CALCA; the disease is familial pancreatic carcinoma.