Therefore, we interbred both KC KrasG12D/fl and KC KrasG12D/+ mice with a mouse carrying an oncogenic mutant Trp53R172H/+ allele, which encodes a dominant-negative p53, equivalent to one commonly found in human pancreatic cancers, thus generating Pdx1-Cre KrasG12D/flTrp53R172H/+ mice (henceforth referred to as KPC KrasG12D/fl). Here, PDX1 is linked to familial pancreatic carcinoma.