KRAS and familial pancreatic carcinoma: Pancreatic cancer was detected in KPC KrasG12D/fl mice via palpation, with confirmation by ultrasound imaging at a median of 50 days of age, in contrast to KPC KrasG12D/+ controls, in which tumor formation was confirmed at a median of 107 days, indicating that loss of WT Kras facilitates tumor initiation (Fig. 3B; Supplementary Fig. S3A and S3C).