A recent study demonstrated that transglutaminase 3 is critical for colonic mucus barrier function, and the absence of transglutaminase activity in mice was associated with increased degradation of MUC2 and altered mucus properties.31 Further research will be necessary to characterize the role of transglutaminases and alterations to Muc2 crosslinking in Giardia infection. This evidence concerns the gene TGM3 and giardiasis.