NLRP3 and diabetic kidney disease: One of the most important studies involving the relationship between the NLRP3 complex and DKD was conducted in 2015 by Shahzad et al. The study showed that knockout of the NLPR3 enzyme or caspase-1 in diabetic mice was able to reduce albuminuria and extracellular matrix accumulation in these animals, but without changing glycemic levels or body weight66.