Perhaps the most prominent GPR34 connection to disease is that GPR34 translocations—associated with 10–100-fold increases in GPR34 transcript abundance—(Baens et al., 2012; Ansell et al., 2012; Akasaka et al., 2017) and putative gain-of-function (GOF) carboxy-terminal (C-terminal) mutations (Moody et al., 2018) recurrently appear in human salivary gland (SG) mucosa-associated lymphoid tissue (MALT) lymphomas. The gene discussed is GPR34; the disease is lymphoma.